Cannabis and Autoimmunity: Possible Mechanisms of Action

Possible Mechanisms of Fullerene C60 Antioxidant Action

Novel mechanism of antioxidant activity of buckminsterfullerene C₆₀ based on protons absorbing and mild uncoupling of mitochondrial respiration and phosphorylation was postulated. In the present study we confirm this hypothesis using computer modeling based on Density Functional Theory. Fullerene's geroprotective activity is sufficiently higher than those of the most powerful reactive oxygen sp...

Possible Mechanisms of Action of Lithium Salts: Approaches and Perspectives

Platman, S. R., Fieve, R. R. & Pierson, R. N. (1970) Arch. Gen. Psychiut. 22, 297-300 Schanberg, S. M., Schildkraut, J. J. & Kopin, I. J. (1967) Biochem. Pharmacol. 16,393-399 Schildkraut, J. J., Schanberg, S. M. & Kopin, 1. J. (1966) Life Sci. 5 , 1479-1483 Schildkraut, J. J., Lodge, M. A. &Dodge, G. A. (1969~) Psychopharrnacologia 14, 135-141 Schildkraut, J. J., Schanberg, S. M. & Breese, G. ...

Phytoestrogens and Breast Cancer Prevention: Possible Mechanisms of Action

OBJECTIVE Phytoestrogens display an array of pharmacologic properties, and in recent years investigation of their potential as anticancer agents has increased dramatically. In this article we review the published literature related to phytoestrogens and breast cancer as well as suggest the possible mechanisms that may underlie the relationship between phytoestrogens and breast cancer. DATA SO...

Mechanisms of tolerance and autoimmunity.

Mechanisms of Autoimmunity

Autoantibodies and autoreactive T cells, which exist even in healthy individuals, are usually regulated by a mechanism called immunological tolerance. For example, peripheral T cells are subject to various types of regulatory mechanisms, including clonal deletion, anergy, clonal ignorance, and T cells with regulatory functions. It is believed that autoimmune response may initiate when such regu...